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Past Rounds

Since its inception, nine calls for funding have been approved for the Joint Funding Scheme and 125 projects for which funding might otherwise might not have been available, have been supported through this scheme.

While no differentiation is made between charities or disease areas, the scheme has been particularly beneficial for rare diseases where research being undertaken internationally may be limited.

Round 8 Joint Funding Scheme 2016 

CharityPrinciple InvestigatorTitle
Diabetes Ireland Research AllianceProf Timothy O’BrienIdentifying the Aetiology of Diabetic Progenitor Cell Dysfunction in Osteoporosis
Irish Cancer Society, Alzheimer Society of Ireland, Diabetes Ireland & The Irish Heart FoundationProf David HeveyPeer-to-peer motivational interview intervention for smoking, alcohol and physical activity among at-risk adolescents in low SES communities: A Feasibility trial
Cystinosis IrelandDr Minnie SarwalTargeting Autophagy in Nephropathic Cystinosis
Cystinosis IrelandProf Elena LevtchenkoUnravelling the mechanisms of Azoospermia and potential future treatments in male Cystinosis patients
Epilepsy IrelandProf David HenshallMicroRNAs in the mechanism of ketogenic diet therapies and as biomarkers in paediatric Epilepsy
Irish Nephrology SocietyProf Mark LittleAVERT: Autoimmunity Relapse Prediction Using Multiple Parallel Data Sources
Fighting BlindnessProf James LoughmanPioneering Advances for Control of Myopia in Children- The Shield Initiative
Fighting BlindnessProf Jane FarrarApplication of Next Generation Sequencing for the Genetic Characterisation of Irish Retinal Degeneration Patients
Arthritis IrelandProf Anthony Gerry WilsonAn Investigation of the mechanisms linking C5orf30 with tissue damage in Rheumatoid Arthritis
Arthritis IrelandProf Ursula Fearon Resolution of inflammation by metabolic reprogramming in the inflamed joint
The Irish Thoracic SocietyProf Joseph KeaneTowards host-directed therapies to overcome immune impairment in cigarette smokers during mycobacterial infection
Muscular Dystrophy IrelandProfessor Kay OhlendieckComparative mass spectrometric profiling of the dystrophin complexome in normal versus pathological muscles with differing degrees of fibre degeneration
Muscular Dystrophy IrelandDr Melissa BowermanRole of TWEAK/Fn14 pathway in mediating muscle pathology in SMA
St Patricks Mental Health HospitalProf Declan McLoughlinKetamine for Relapse Prevention in Recurrent Depressive Disorder: a randomised, controlled pilot trial (The KINDRED Trial)
Breakthrough Cancer ResearchDr Mark TangneyBacteria in Human Tumours
Charity Principle Investigator Title
Diabetes Ireland Research Alliance Prof Timothy O’Brien Identifying the Aetiology of Diabetic Progenitor Cell Dysfunction in Osteoporosis
Irish Cancer Society, Alzheimer Society of Ireland, Diabetes Ireland & The Irish Heart Foundation Prof David Hevey Peer-to-peer motivational interview intervention for smoking, alcohol and physical activity among at-risk adolescents in low SES communities: A Feasibility trial
Cystinosis Ireland Dr Minnie Sarwal Targeting Autophagy in Nephropathic Cystinosis
Cystinosis Ireland Prof Elena Levtchenko Unravelling the mechanisms of Azoospermia and potential future treatments in male Cystinosis patients
Epilepsy Ireland Prof David Henshall MicroRNAs in the mechanism of ketogenic diet therapies and as biomarkers in paediatric Epilepsy
Irish Nephrology Society Prof Mark Little AVERT: Autoimmunity Relapse Prediction Using Multiple Parallel Data Sources
Fighting Blindness Prof James Loughman Pioneering Advances for Control of Myopia in Children- The Shield Initiative
Fighting Blindness Prof Jane Farrar Application of Next Generation Sequencing for the Genetic Characterisation of Irish Retinal Degeneration Patients
Arthritis Ireland Prof Anthony Gerry Wilson An Investigation of the mechanisms linking C5orf30 with tissue damage in Rheumatoid Arthritis
Arthritis Ireland Prof Ursula Fearon  Resolution of inflammation by metabolic reprogramming in the inflamed joint
The Irish Thoracic Society Prof Joseph Keane Towards host-directed therapies to overcome immune impairment in cigarette smokers during mycobacterial infection
Muscular Dystrophy Ireland Professor Kay Ohlendieck Comparative mass spectrometric profiling of the dystrophin complexome in normal versus pathological muscles with differing degrees of fibre degeneration
Muscular Dystrophy Ireland Dr Melissa Bowerman Role of TWEAK/Fn14 pathway in mediating muscle pathology in SMA
St Patricks Mental Health Hospital Prof Declan McLoughlin Ketamine for Relapse Prevention in Recurrent Depressive Disorder: a randomised, controlled pilot trial (The KINDRED Trial)
Breakthrough Cancer Research Dr Mark Tangney Bacteria in Human Tumours

Round 7 Joint Funding Scheme 2014 

Charity Research Institution Principal Investigator Title
Alpha One RCSI Dr Emer P. Reeves Altered lipid raft cholesterol content contributes to the dysregulated activity of neutrophils in alpha-1 antitrypsin deficiency
Alpha One RCSI Professor Noel McElvaney Alpha-1 antitrypsin deficiency: Which is important phenotype, level, activity or all three?
Fighting Blindness University College Dublin Dr Breandan Kennedy Identification of drugs that can safely and effectively maintain visual function in models of inherited retinal degeneration
Fighting Blindness Queen’s University Belfast Dr Giuliana Silvestri Inherited Retinal Degenerations: All Ireland Retinal Degenerations Partnership (AIRDP)
Royal Victoria Eye and Ear Royal College of Surgeons in Ireland Professor Conor Murphy Restoring immune balance in patients with patients with primary Sjogrens Syndrome (pSS) by modulating microRNA expression
Irish Thoracic Society University College Cork Professor Fergal O’Gara Investigate the impact of bile aspiration on chronic respiratory infection – Bile Paradigm
Cystinosis Ireland The University of Auckland Professor Alan J. Davidson Modelling cystinosis with human stem cells and the therapeutic potential of aspartate
Cystinosis Ireland University of Florida Professor Anuj Chauhan Drug Eluting Contact Lenses for Cystinosis Therapy

Round 6 Joint Funding Scheme 2013

Charity Principal Investigator Project Title
Alpha One Foundation Dr Emer P. Reeves Post-translational modifications modify the anti-inflammatory
effect of alpha-1 antitrypsin
Children’s Fund for Health Ltd Dr Sally Ann Lynch Identification of the genetic causes of developmental delay with mitochondrial dysfunction in the Irish Traveller population
 Epilepsy Ireland  Dr Naomi Elliott  The collaborative development of an evidence-based educational resource for self-disclosure strategies for people with epilepsy. (How-To-Tell)
 Fighting Blindness  Prof. Jane Farrar  Genetic characterisation of a cohort of Irish retinal degeneration patients
 Friends of the Rotunda  Professor Fergal Malone  The HANDLE Study: HEMODYNAMIC Assessment in pregnancy and neonatal Echocardiography assessment. A study identifying Abnormal Hemodynamic Profiles in Pregnancy as a Predictor of Adverse Obstetric Outcome and Characterisation of Neonatal Myocardial Performance in Infants.
 Irish Cancer Society  Professor Pamela Gallagher  Self-Management for Head and Neck Cancer Survivors: Living Well With and Beyond HNC
 Irish Thoracic Society  Prof Noel Gerard McElvaney  Ignoring the Nonsense – Personalised Medicine for Genetic Lung Disorders
 Irish Thoracic Society  Dr Barry Plant  Clinical implications and utility of an endotoxin-tolerant state in cystic fibrosis

Round 5 Joint Funding Scheme 2012

Charity Principal Investigator Project Title Research Institution
Alpha One Foundation Dr Emer Reeves Regulation of neutrophil membrane receptor profile and signalling by serum alpha-1 antitrypsin. RCSI
Children’s Fund for Health Prof. Eileen Treacy Galactosaemia, a modifiable multi-system glycosylation disorder? Children’s University Hospital Temple Street
Irish Cancer Society B. Therese Kinsella Thromboxane (TX)A2 -mediated PRK1 signalling in Prostate Cancer: University College Dublin
Fighting Blindness Prof Jane Farrar Exploration of AAV-delivered gene therapies for LHON TCD
Brainwave Professor Agnes Higgins An evaluation of the role of the Epilepsy Specilist Nurse and the impact on patient quality of life RCSI
Brainwave Dr Veronica Lambert Demystify the veil of secrecy: a mixed method inquiry of parent-child dialogue about epilepsy and its associated stigma Dublin City University
Research Foundation Royal Victoria Eye and Ear Hospital Dr Caroline Jefferies Profilling Toll-loke receptor responses in patients with primary Sjogren’s syndrome RCSI
The Alzheimer Society of Ireland Brian Lawlor Cognitive function, caregiver stress an cortisol: Mechanisms and implications for prvention of adverse health consequences in spouse Trinity College Dublin
National Chilldren’s Research Centre/Children’s Medical and Research Foundation Dr Sean Ennis The characterization of recessive mutations in homozygous haplotypes implicated in Autism Sepctrum Disorders National Chrildren’s Research Centre, Crumlin Hospital
Bee For Battens , The Saoirse Foundation Dr Jonathan Cooper Glial dysfunctino in muktiple forms of NCL: new directions for therapy Institute of Psychiatry, Kings College London
Bee For Battens , The Saoirse Foundation Steven J Gray Global Gene Transfer for the treatment of Batten Disease The University of North Carolina at Chapel hill

Round 4 Joint Funding Scheme 2011

Charity Principal Investigator Host Institution Project Title Duration
Alpha One Emer Reeves RCSI Control of lipid induced granule exocytosis in neutrophils: therapeutic potential of alpha-1 antitrypsin. 3 Years
Alpha One David Bergin RCSI The role of carbohydrate residues in Alpha-1 antitrypsin anti-protease and anti-inflammatory properties. 3 Years
Brainwave David C. Henshall RCSI Genome-wide DNA methylation analysis of hippocampus from patients with pharmacoresistant temporal lobe epilepsy. 1 Year, 6 Months
Cystic Fibrosis Association of Ireland Eileen Savage UCC National Prevalence of Depression and Anxiety in Patients with cystic fibrosis and Parents: Impact on Health and Quality of Life. 3 Years
Cystic Fibrosis Association of Ireland Marguerite Clyne UCD The role of mucus and mucins in mediating Pseudomonas aeruginosa colonization of the cystic fibrosis lung. 3 Years
Diabetes Federation of Ireland Ronan Conroy RCSI What factors influence self-care and Quality of Life in young Irish adults (aged 23-30) with Type 1 diabetes? 1 Year
Fighting Blindness Peter Humphries TCD Exploration of the candidacy of RPE65 in the etiology of adRP with choroidal involvement 3 Years
Fighting Blindness Jane Farrar TCD Stem cell therapies for the treatment of diverse retinal disorders. 3 Years
Irish Cancer Society Ciaran Morrison NUIG Centrosome amplification and radiosensitisation of prostate cancer cells. 3 Years
Irish Cancer Society Laura Barkley – Elliman NUIG Therapeutic microRNA control of Prostate Cancer growth. 1 Year, 6 Months
Multiple Sclerosis Ireland Una Fitzgerald NUIG Polymer-mediated delivery of endoplasmic reticulum stress altering siRNA to oligodendroyctes in a cerebellar rat brain slice model of de- and remyelination. 3 Years
National Childrens Research Charity Sally Ann Lynch UCD Indentifying recessive genes for primary ciliary dyskinesia, microepaly and dilated cardiomyopathy. 2 years
National Childrens Research Charity Sean Ennis NCRC Genomics of paediatric autism spectrum disorder 3 Years

Round 3 Joint Funding Scheme 2009

Charity Principal Investigator Project Title Duration
Alpha One Prof Noel G McElvaney Accelerated neurophil apoptosis is associated with alpha-1 antitrypsin deficiency 3 Years
Alpha One Dr Catherine Greene Phosphatidylinositol 3-Kinasd (PI3K): a molecular target of ER stress induced by Z alpha -1 antitrypsin? 3 Years
Association of Friends of St. Patricks Hospital Prof Paul Fearon Measuring quality of care in an Irish Mental Health Service Context 3 Years
Brainwave: The Irish Epilepsy Association Dr Evelyn T Burke Heritability of cognitive endophenotypes in temporal lobe epilepsy: A neuropsychological investigation 1 Year 6 months
Brainwave: The Irish Epilepsy Association Dr Gianpiero Cavalleri A pharmacogenomic study of chronic refractory epilepsy 3 Years
Children’s Medical and Research Foundation Dr Maureen J O’Sullivan The role of Epigenetic Modification and miRNAs in the Development of Pediatric Gastrointestinal Stromal tumour (GIST) 3 Years
Cystinosis Foundation Ireland Dr Philip Newsholme Molecular mechanisms of muscle myopathy and pancreatic beta cell dysfunction associated with Cystinosis: Determination of optimal approaches for cell protection 3 Years
Duchenne Ireland Dr Helge Amthor Can exon skipping therapy restore the mitrochondiral metabolism in animal models for DMD 1 Year
Duchenne Ireland Prof Volker Straub Identifying the biodistribution of antisense oligonucleotides in the mdx mouse by Magnetic Resonance Imaging 2 Years
Irish Cancer Society Dr Mark Lawler Hypermethylation in prostate cancer: further evaluation of GSTP1, SFRP2 and IGFBP3 as prognostic biomarkers and unmasking of epigenetically controlled miRNAs 3 Years
Irish Cancer Society Dr Rosemary O’Connor To determine how RACK1 regulations cell migration during tissue morpohgenesis and tumorigenesis using 3D culture model systems 3 Years
Irish Cancer Society Prof Afshin Samali Uncoupling of death receptor-induced nuclear factor kappa B activation from apoptosis 3 Years

Round 2 Joint Funding Scheme 2007

Charity Principal Investigator Project Title Duration
Alpha One Prof N.G.McElvaney Anti-inflammatory effect of Alpha 1-antitrypsin on the phagocytic neutrophil 3 Years
Irish Heart Foundation Prof J Feely Choice of antihypertensive agent in newly diagnosed patients and in those patients not responding to therapy 2 Years
Irish Heart Foundation Dr B Hynes Cardiac Angiogenesis: “Cell Based Bypass” of chronic vascular occlusions 2 Years
Cystic Fibrosis Dr C Gallagher Gender Differences in Muscle Dysfunction and Electrical Muscle Stimulation in Cystic Fibrosis 3 Years
Cystinosis Dr Patrick Harrison Development of an in vitro gene repair kit: towards a cure for cystinosis 3 Years
Cystinosis Dr Minnie Sarwal Investigation of a Mechanism That Can Prevent Renal Injury in the Patients with Nephropathic Cystinosis. 3 Years
DEBRA Dr Jane Farrar Evaluation of RNAi-based therapeutic approaches for dominant dystrophic Epidermolysis Bullosa 3 Years
Diabetes Federation of Ireland Sean Dinneen The Galway Diabetic Foot Study: Epidemiology, Cost, Feasibility, and Implications for Clinical Practice and Policy 3 Years
Fighting Blindness Jane Farrar Exploration of stem cell-based therapies for retinal degenerations 3 Years
Irish Cancer Society Tom Cotter Redox regulation of apoptosis modulating survival pathways in re-current tumours 3 Years
Irish Cancer Society  Shaun McCann Infusion of mesenchymal stem cells in patients with steroid resistant acute grade II to IV GvHD: a prospective double-blind randomized study 3 Years

Round 1 Joint Funding Scheme 2006

Charity Principal Investigator Project Title Duration
Research Institute for a Tobacco Free Society Professor Luke Clancy ‘The effect of the Irish workplace smoking ban on birth weight and gestational age at birth’. 1 Year
Research Institute for a Tobacco Free Society Dr. Patrick Goodman ‘A study of environmental tobacco smoke exposure within unexempted premises – nursing homes as defined in the Public Health Acts 2002 and 2004’. 2 Years
Mater Foundation Professor P. Ronan O’ Connell ‘Investigation of fibroblast gene expression profiles associated with the development of fibrostenosing phenotype in Crohns disease’. 3 Years
Mater Foundation Dr. Maria Byrne The effect of Insulin therapy on beta cell survival in patients with Maturity onset diabetes of the young (MODY) 3′ 3 Years
Alpha One Foundation Thomas P. Carrol ‘Elucidation of unfolded protein response pathways activated in lung and liver disease associated with XZ alpha-1 antitrypsin deficiency’. 3 years
Alpha One Foundation Catherine M. Greene ‘Identification and characterisation of novel proinflammatory proteases that exacerbate lung disease associated with Z Alpha -1 antitrypsin deficiency’. 3 Years
Muscular Dystrophy Ireland Professor Kay Ohlendieck ‘Identification of novel biomakers in dystrophic heart and muscle fibres using comparative proteconomics’ 3 Years
Muscular Dystrophy Ireland Joe Mooney ‘Safety testing of an antisense oligonucleotide for exon 51 skipping in the treatment of Duchenne muscular dystrophy’. 1 Year
Fighting Blindness Mr. Stephen Beatty ‘Spatial profile of macular pigment in relation to risk for age-related macular degeneration’. 3 Years
Fighting Blindness Brendan N. Kennedy ‘Directing retinal stem cells to become functionally integrated coen photoreceptors in host retinas’. 3 Years
Fighting Blindness Marius Ader ‘The development of cell based therapies for the treatment of photoreceptor degeneration in mouse models of retinitis pigmentosa’. 3 Years
Fighting Blindness Peter Humphries ‘On the molecular pathology of retinal degradation caused by mutations within the IMPDH1 gene’. 3 Years
Diabetes Federation of Ireland Dr. Donal O’ Shea ‘Adipocyte size and type 2 diabetes in obesity – a study of patients undergoing bariatric surgery’. 3 Years
The Cystic Fibrosis Association of Ireland Edward F. McKone ‘Genetic modifiers of the cystic fibrosis phenotype’. 3 Years
DEBRA Ireland Professor Abhay Pandit ‘A biodegradable nanoshell for targeted gene delivery of type VII collagen’. 3 Years
Irish Cancer Society Dermot Kelleher ‘Tribbles homolog 3 a novel regulator of carcinogen signalling in oesophageal cells’. 3 Years
Irish Cancer Society Professor Mark Lawlor ‘Identifying and evaluating novel methylation biomakers in prostate cancer’. 3 Years
Irish Cancer Society Sharon McKenna Influence of Bcr-Abl on ER initiated apoptosis, and novel targeting strategies for Bcr-Abl expressing leukemias’. 3 Years
Irish Cancer Society Professor Gerald C. O’ Sullivan Immune reactivity to foregut cancers- investigation into mechanism of oral tolerance’. 3 Years
Irish Cancer Society Dr. Wiliam Watson ‘Proteonomic analsyis of urine from prostate cancer patients – translating the proteonome to clinical biomarkers’. 3 Years
Irish Cancer Society John Reynolds ‘Identification and validation of early predcitive serums markers of response to neoadjuvent radiochemotherapy in rectal and oesophageal cancer’. 3 Years
Irish Cancer Society Verna Amberger – Murphy ‘Investigation in signalling pathways in high grade glioma in order to predict responsiveness to tyrosine kinase inhibitors’. 3 Years
Irish Cancer Society Margaret McGee ‘Small molecule cycophilin A inhibitors as novel anticancer therapeutics’. 3 Years
Irish Cancer Society Professor Stephen Eustace ‘A targeted contrast agent for multiple myeloma’ 3 Years
Irish Heart Foundation Dr. R Watson ‘Analysis of neutrophil migratory potential as a predictive marker of human cardiac transplant rejection’. 3 Years
Irish Heart Foundation Thomas Barron ‘Long term adherence to cardiovascular therapy in Irish populations’. 2 Years
Irish Heart Foundation Dr. Emma Stokes ‘FAME – a randomized controlled trial of family mediated exercise intervention following a stroke’. 3 Years
Irish Heart Foundation Dr. James O’ Donnell ‘Development of the endogenous thrombin potential assay as a novel approach to characterising global coagulation status in patients with arterial thrombosis’. 2 Years
The Childrens Medical and Research Foundation Professor JM Redmond ‘Omega 3 fatty acid and glutamine pretreatment’. 2 Years
The Childrens Medical and Research Foundation Dr. Niamh O’ Sullivan ‘Rapid early detection and molecular profiling of Pseudomonas aeruginosa isolates in Paediatric Cystic Fibrosis Patients 3 Years
Meningitis Research Foundation Dr. Ed Lavelle ‘The identification of novel immunomodulatory factors from Neisseria memingitidis subgroup B’. 3 Years
Asthma Society of Ireland John L. Faul ‘The role of natural T cells in human asthma’. 3 Years
Cystinosis Foundation of Ireland Dr. Donal Cairns ‘Design, formulation and biological evaluation of novel prodrugs for the treatment of Cystinosis’. 2 Years

Link to Irish Government websiteLink to Pobal websiteLink to Health Research Board website