Alpha-1 is a genetic condition resulting in serious lung and/or liver disease. Alpha One Foundation recently completed a research project funded by the Joint Funding Scheme that changes current thinking in the field of Alpha-1. This research focused on lung disease in Alpha-1 patients – and investigated how the normal function of cells are impaired. The study showed for the first time how the immune response in Alpha-1 patients is exaggerated. These novel findings will form the basis of future Alpha-1 projects.
Around one-third of epilepsy patients have severe epilepsy which is resistant to medication. A recent study explored the role of genes in patients’ responses to drug treatment. Understanding the genetics of drug response offers the potential to tailor treatment to the individual. Epilepsy Ireland carried out this project with The Royal College of Surgeons Ireland in order to build the knowledge base required to provide optimal holistic care to individuals with epilepsy and related disorders.
Alzheimer’s Society of Ireland, Diabetes Ireland, the Irish Cancer Society, and the Irish Heart Foundation
Smoking, alcohol consumption, and physical inactivity can contribute to ill health, including cancer, heart disease, diabetes, and dementias such as Alzheimer’s disease. Unfortunately, these behaviours often begin in adolescent are more common in communities with a lower socio-economic status.
In 2016, a team of researchers, led by Professor David Hevey of Trinity College Dublin, wanted to reduce these negative health behaviours at their source; during adolescence. The team were awarded a grant under the HCRI/HRB Joint Funding Scheme to examine the feasibility and effectiveness of peer-led health behaviour change intervention among at-risk adolescents. The project aimed to have a positive impact on smoking rates, alcohol consumptions, and physical activity in young people.
The research team trained 16 young adults to deliver the intervention using a counselling technique called motivational interviewing. These young adults then worked with their peers to encourage positive health behaviours (for example, exercise) and discourage negative health behaviours (such as smoking).
In total, the young adults delivered the intervention to 64 of their peers, finding that their peers were significantly more likely to increase their exercise, and to decrease their smoking and alcohol consumption behaviours.
Professor Hevey’s team was able to demonstrate the young adults were confident and capable in delivering peer-led interventions and that this intervention was effective in improving health behaviours among young people.
Fighting Blindness funded research in Trinity College Dublin that discovered the gene responsible for a form of inherited blindness. This has led to gene therpay clinical trials which are currently in progress. “Research funded by Fighting Blindness was absolutely crucial to building the international reputation of The Smurfit Institute of Genetics at Trinity College Dublin. It led to several major discoveries on the genetic causes of blindness.”
Prof David McConnell, Head of School of Genetics, Trinity College Dublin.
Cystinosis Foundation Ireland
Cystinosis is a genetic metabolic disease affecting multiple organs and resulting in kidney failure. Since 2005, a research team in UCC has been developing a technique to repair the mutated genes which cause Cystinosis. In January 2009, with a grant received from the Joint Funding Scheme, they started to apply this technique to mutations in the Cystinosis gene. After presenting the preliminary data at a Research Symposium in California in April 2010, the team secured an additional $150K from a US-based Cystinosis charity to extend the research activity. Two teams of researchers are now employed at UCC, leading innovative, internationally-recognised scientific research in this area.
Diabetes Ireland Research Alliance
The estimated in-patient cost of treating preventable diabetic foot disease in Ireland was €239 million between 2005-2009. The West of Ireland Foot Study commenced in July 2008. It was a 3-year research study investigating the prevalence, incidence and cost of diabetes foot problems (ulcers) in the west of Ireland. Training on diabetes foot care was delivered to all participating practices. The study has raised awareness among primary care staff of the importance of diabetes foot screening. Resulting from this study, The School of Podiatry NUI Galway have developed a short course in diabetes foot screening for health care professionals. Model can now be used nationally for the delivery of quality foot care.